PerioMed 0.63% Stannous Fluoride Oral Rinse — Prescription-Strength

PerioMed is a prescription-strength 0.63% stannous fluoride oral rinse used daily to strengthen enamel, control plaque, and calm gum inflammation. It delivers stannous fluoride — a form of fluoride with both anti-cavity and antibacterial action — making it a versatile daily rinse for people who need more protection than an over-the-counter mouthwash provides.

Stannous fluoride works in two ways: the fluoride remineralizes and hardens enamel against acid and decay, while the stannous (tin) component reduces the bacteria that drive plaque buildup and gum irritation. Unlike chlorhexidine, it does not stain with long-term use, so it is well suited to ongoing daily care rather than short courses.

How to use

PerioMed is a concentrate that you mix with water in the measuring cup immediately before each use — mixing it fresh keeps the stannous fluoride fully active (pre-mixing several days’ worth reduces its potency). Swish for one minute, then spit — do not rinse, eat, or drink for 30 minutes afterward so the fluoride stays on the teeth. Use once daily, usually at bedtime, or as directed by your dentist.

Who it's for

A daily option for adults who want stronger protection against cavities and plaque than standard mouthwash, including those with a history of frequent decay, exposed root surfaces, orthodontic appliances, or reduced saliva. Your dentist will confirm it's appropriate for you through a brief telehealth review.

Related reading from Soothing Dental: what to do when gum problems don't improve.

Frequently Asked Questions

How is PerioMed different from a regular mouthwash?

Over-the-counter mouthwashes are mostly cosmetic or contain low-level fluoride. PerioMed is a prescription-strength 0.63% stannous fluoride rinse that both hardens enamel against decay and reduces the bacteria that cause plaque and gum inflammation — with antimicrobial activity lasting up to about 8 hours. That dual action isn’t available over the counter.

How do I mix and use it?

PerioMed comes as a concentrate. Mix it with water in the provided cup right before each use — don’t pre-mix days in advance, as that lowers its strength. Swish for one minute, spit, and avoid eating, drinking, or rinsing for 30 minutes. Use once daily, preferably at bedtime, or as directed by your dentist.

Will it stain my teeth like chlorhexidine?

No. Unlike chlorhexidine (Peridex), which is meant for short 2-week courses because it stains with prolonged use, stannous fluoride is suitable for ongoing daily use without that staining — so it fits a long-term routine.

What is PerioMed used for?

It’s used to help prevent and control gingivitis, strengthen enamel against cavities, and reduce tooth sensitivity — making it a good daily option for people at higher risk of decay or gum problems than a standard mouthwash addresses.

Do I need a prescription?

Yes — PerioMed 0.63% stannous fluoride is a prescription product. Soothing Dental’s team reviews your eligibility through a brief telehealth screen, and a complimentary Rx review is included with your order.