Colgate PreviDent 5000 Booster Plus, Sensitive & Dry Mouth — Prescription-Strength Fluoride Toothpaste

Colgate PreviDent 5000 is the classic 5000 ppm sodium fluoride prescription toothpaste — a prescription-strength toothpaste for people who need extra cavity protection beyond a standard over-the-counter toothpaste. Use once daily in place of regular toothpaste.

Three variants are available here. Choose the one that matches your needs:

PreviDent 5000 Booster Plus

The original Colgate PreviDent 5000 Booster Plus formulation — 1.1% sodium fluoride (5000 ppm) for adults with high cavity risk. Mint flavor. Use this if you don't have specific sensitivity or dry-mouth concerns and just want prescription-strength fluoride.

PreviDent 5000 Sensitive (with Potassium Nitrate)

The PreviDent 5000 Sensitive variant adds 5% potassium nitrate to the Rx-strength fluoride content. Potassium nitrate calms the nerve endings inside dentinal tubules — most patients notice reduced sensitivity within about 2 weeks of daily brushing. Pick this if you have sensitive teeth alongside high cavity risk.

PreviDent 5000 Dry Mouth (SLS-Free)

The PreviDent 5000 Dry Mouth variant is SLS-free. Sodium Lauryl Sulfate (SLS) is a foaming agent that typically exacerbates dryness of the soft tissue; SLS-containing toothpastes can feel more irritating to the cheeks and gums, so an SLS-free option is gentler. The SLS-free formulation is a good choice for anyone who prefers a gentler, less-drying formula.

Curated and shipped by Soothing Dental, San Francisco. Soothing Dental's team reviews Rx eligibility through a brief telehealth screen when the order is placed — a complimentary Rx review is included.

Related reading from Soothing Dental: Learn more about non-invasive cavity prevention with Curodont.

Frequently Asked Questions

How is PreviDent 5000 different from regular fluoride toothpaste?

Regular over-the-counter toothpaste has 1450 ppm sodium fluoride. Colgate PreviDent 5000 has 5000 ppm — 3.4× the strength — and is FDA-classified as a prescription dental product. It's used by adults who need stronger cavity protection than a standard toothpaste provides.

PreviDent 5000 Booster Plus vs PreviDent 5000 Sensitive — which to pick?

If you don't have tooth sensitivity, pick the original Booster Plus. If you have sensitive teeth, pick PreviDent 5000 Sensitive — it adds potassium nitrate to address sensitivity alongside the prescription fluoride. Both are 5000 ppm sodium fluoride for cavity prevention.

PreviDent 5000 vs Clinpro 5000 vs CariFree Pro Gel 5000 — which one?

All three deliver 5000 ppm sodium fluoride. PreviDent is Colgate's classic mint formulation; Clinpro 5000 is 3M's version with functionalized tri-calcium phosphate (fTCP) for added remineralization, available in Mint and Bubble Gum; CariFree Pro Gel 5000 adds elevated pH plus nano-hydroxyapatite, available in Mint and Citrus. Choice comes down to flavor preference, texture, and your dentist's protocol — all are effective prescription-strength cavity prevention toothpastes.

Is the PreviDent 5000 Dry Mouth variant the same SLS-free product as in dental offices?

Yes — the PreviDent 5000 Dry Mouth SLS-free formulation we ship is the same Colgate prescription product used in dental practices. It's specifically formulated without sodium lauryl sulfate (SLS) for a gentler, less-drying feel.

Can I use PreviDent 5000 with MI Paste Plus?

Yes — many high-risk patients use both. Brush with PreviDent 5000 in the morning, and apply MI Paste Plus at night for an additional layer of calcium/phosphate remineralization. Your dentist can confirm the right protocol for your case.

Do I need a prescription?

Yes — 5000 ppm fluoride toothpaste is FDA-classified as prescription. Soothing Dental's team reviews Rx eligibility through a brief telehealth screen when your order is placed.