Colgate PreviDent 5000 Booster Plus, Sensitive & Dry Mouth — Prescription-Strength Fluoride Toothpaste

Colgate PreviDent 5000 is the classic 5,000 ppm fluoride prescription toothpaste — a prescription-strength toothpaste for people who need extra cavity protection beyond a standard over-the-counter toothpaste. Each formula has its own directions, listed below. Follow your formula's label and your dentist's instructions, and use it in place of your regular toothpaste.

Three variants are available here. Choose the one that matches your needs:

PreviDent 5000 Booster Plus

The original Colgate PreviDent 5000 Booster Plus formulation — 1.1% sodium fluoride (5,000 ppm fluoride) for people at higher risk of cavities. Mint flavor. Use this if you don't have specific sensitivity or dry-mouth concerns and just want prescription-strength fluoride.

Directions (adults and children 6 and older): brush with a thin ribbon once a day for two minutes, preferably at bedtime. Adults spit it out and, for best results, don't eat, drink, or rinse for 30 minutes. Children ages 6–16 spit it out and rinse their mouth thoroughly.

PreviDent 5000 Sensitive (with Potassium Nitrate)

The PreviDent 5000 Sensitive variant adds 5% potassium nitrate to the prescription-strength fluoride. It helps reduce painful sensitivity of the teeth to cold, heat, acids, sweets, or touch, alongside cavity protection. Pick this if you have sensitive teeth alongside high cavity risk.

Directions (adults and children 12 and older): brush with at least a 1-inch strip on a soft toothbrush twice a day, morning and evening, for at least one minute, then spit it out and rinse your mouth thoroughly. Don't use it for longer than 4 weeks unless a dentist or physician recommends it. Sensitive teeth may indicate a serious problem that may need prompt care by a dentist. See your dentist if the sensitivity persists or worsens. Children under 12: ask a dentist or physician.

PreviDent 5000 Dry Mouth (SLS-Free)

PreviDent 5000 Dry Mouth is formulated without sodium lauryl sulfate (SLS), a foaming agent. Pick this if you prefer an SLS-free toothpaste.

Directions (adults and children 6 and older): brush with a thin ribbon once a day for two minutes, preferably at bedtime. Adults spit it out and, for best results, don't eat, drink, or rinse for 30 minutes. Children ages 6–16 spit it out and rinse their mouth thoroughly.

Safety

• Do not swallow. Swallowing too much fluoride can cause nausea and vomiting.
• Keep out of reach of children. Not for children under 6 (under 12 for Sensitive) unless a dentist or physician directs it, and children under 12 should be supervised when using it.
• If you are nursing or have kidney problems, ask your dentist or physician before using it.

Curated and shipped by Soothing Dental, San Francisco. When you order, you answer a short health questionnaire, and a licensed dentist reviews it before your order ships. The review is included at no extra cost.

Related reading from Soothing Dental: Learn more about non-invasive cavity prevention with Curodont.

Frequently Asked Questions

How is PreviDent 5000 different from regular fluoride toothpaste?

Most regular fluoride toothpastes in the US contain about 1,000–1,100 ppm fluoride (some up to about 1,500 ppm). Colgate PreviDent 5000 has 5,000 ppm — several times the strength — and it is sold by prescription only. It's for people at higher risk of cavities who need more protection than a standard toothpaste provides.

PreviDent 5000 Booster Plus vs PreviDent 5000 Sensitive — which to pick?

If you don't have tooth sensitivity, pick the original Booster Plus. If you have sensitive teeth, pick PreviDent 5000 Sensitive — it adds potassium nitrate to address sensitivity alongside the prescription fluoride. Both contain 5,000 ppm fluoride for cavity prevention, but their directions differ: Booster Plus is used once a day (ages 6 and up), and Sensitive twice a day followed by rinsing (ages 12 and up).

PreviDent 5000 vs Clinpro 5000 vs CariFree Pro Gel 5000 — which one?

All three deliver 5,000 ppm fluoride. PreviDent is Colgate's classic mint formulation; Clinpro 5000 is 3M's version with functionalized tri-calcium phosphate (fTCP) for added remineralization, available in Mint and Bubble Gum; CariFree Pro Gel 5000 adds elevated pH plus nano-hydroxyapatite, available in Mint and Citrus. Choice comes down to flavor preference, texture, and your dentist's protocol — all are effective prescription-strength cavity prevention toothpastes.

Is the PreviDent 5000 Dry Mouth variant the same SLS-free product as in dental offices?

Yes — the PreviDent 5000 Dry Mouth we ship is the same Colgate prescription product used in dental practices. It is formulated without sodium lauryl sulfate (SLS), a foaming agent.

Can I use PreviDent 5000 with MI Paste Plus?

Many high-risk patients use both. Use PreviDent 5000 as its label directs (Booster Plus and Dry Mouth preferably at bedtime), and ask your dentist when to apply MI Paste Plus so the two fit together in your routine.

Do I need a prescription?

Yes — 5000 ppm fluoride toothpaste is sold by prescription only. When you order from Soothing Dental, you answer a short health questionnaire and a licensed dentist reviews it, at no extra cost, before your order ships.