Colgate PreviDent 5000 Booster Plus, Sensitive & Dry Mouth — Prescription-Strength Fluoride Toothpaste

Colgate PreviDent 5000 is the classic 5000 ppm sodium fluoride prescription toothpaste — used for cavity prevention in patients with elevated decay risk: dry mouth (medication-induced or radiation-related), exposed root surfaces, orthodontic appliances, or recurring caries around crowns or fillings. Use once daily in place of regular toothpaste.

Three variants are available here. Choose the one that matches your needs:

PreviDent 5000 Booster Plus

The original Colgate PreviDent 5000 Booster Plus formulation — 1.1% sodium fluoride (5000 ppm) for adults with high cavity risk. Mint flavor. Use this if you don't have specific sensitivity or dry-mouth concerns and just want prescription-strength fluoride.

PreviDent 5000 Sensitive (with Potassium Nitrate)

The PreviDent 5000 Sensitive variant adds 5% potassium nitrate to the Rx-strength fluoride content. Potassium nitrate calms the nerve endings inside dentinal tubules — most patients notice reduced sensitivity within about 2 weeks of daily brushing. Pick this if you have sensitive teeth alongside high cavity risk.

PreviDent 5000 Dry Mouth (SLS-Free)

The PreviDent 5000 Dry Mouth variant is SLS-free. Sodium Lauryl Sulfate (SLS) is a foaming agent that typically exacerbates dryness of the soft tissue; for patients with dry mouth, SLS-containing toothpastes can create more irritation in the cheeks and gums. The SLS-free formulation is the right choice for moderate to severe xerostomia (dry mouth) — whether from medication, radiation, Sjögren's syndrome, or other causes.

Curated and shipped by Soothing Dental, San Francisco. Soothing Dental's team reviews Rx eligibility through a brief telehealth screen when the order is placed — a complimentary Rx review is included.

Related reading from Soothing Dental: Learn more about non-invasive cavity prevention with Curodont.

Frequently Asked Questions

How is PreviDent 5000 different from regular fluoride toothpaste?

Regular over-the-counter toothpaste has 1450 ppm sodium fluoride. Colgate PreviDent 5000 has 5000 ppm — 3.4× the strength — and is FDA-classified as a prescription dental product. It's used for adults with high cavity risk: dry mouth, exposed root surfaces, orthodontic appliances, or recurring decay around restorations.

PreviDent 5000 Booster Plus vs PreviDent 5000 Sensitive — which to pick?

If you don't have tooth sensitivity, pick the original Booster Plus. If you have sensitive teeth, pick PreviDent 5000 Sensitive — it adds potassium nitrate to address sensitivity alongside the prescription fluoride. Both are 5000 ppm sodium fluoride for cavity prevention.

PreviDent 5000 vs Clinpro 5000 vs CariFree Pro Gel 5000 — which one?

All three deliver 5000 ppm sodium fluoride. PreviDent is Colgate's classic mint formulation; Clinpro 5000 is 3M's version with functionalized tri-calcium phosphate (fTCP) for added remineralization, available in Mint and Bubble Gum; CariFree Pro Gel 5000 adds elevated pH plus nano-hydroxyapatite, available in Mint and Citrus. Choice comes down to flavor preference, texture, and your dentist's protocol — all are effective prescription-strength cavity prevention toothpastes.

Is the PreviDent 5000 Dry Mouth variant the same SLS-free product as in dental offices?

Yes — the PreviDent 5000 Dry Mouth SLS-free formulation we ship is the same Colgate prescription product used in dental practices. It's specifically formulated without sodium lauryl sulfate (SLS) to avoid worsening soft-tissue dryness in patients with xerostomia.

Can I use PreviDent 5000 with MI Paste Plus?

Yes — many high-risk patients use both. Brush with PreviDent 5000 in the morning, and apply MI Paste Plus at night for an additional layer of calcium/phosphate remineralization. Your dentist can confirm the right protocol for your case.

Do I need a prescription?

Yes — 5000 ppm fluoride toothpaste is FDA-classified as prescription. Soothing Dental's team reviews Rx eligibility through a brief telehealth screen when your order is placed.